Stanford News: “Stanford single-dose nanoparticle vaccine for COVID-19”

Our goal is to make a single-shot vaccine that does not require a cold-chain for storage or transport. If we’re successful at doing it well, it should be cheap too, said Kim, who is the Virginia and D. K. Ludwig Professor of Biochemistry. The target population for our vaccine is low- and middle-income countries.

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After a single dose, the two nanoparticle vaccine candidates both resulted in neutralizing antibody levels at least twice as high as those seen in people who have had COVID-19, and the shortened spike nanoparticle vaccine produced a significantly higher neutralizing response than the binding spike or the full spike (non-nanoparticle) vaccines. After a second dose, mice that had received the shortened spike nanoparticle vaccine had the highest levels of neutralizing antibodies.

Taylor Kubota

Can’t wait for the reactions of conspiracy theorists when they see the word ‘nanoparticle’… 😏

A schematic visualization of the ferritin nanoparticle with shortened coronavirus spike proteins, which is the basis of a SARS-CoV-2 vaccine candidate from Stanford. (Image credit: Duo Xu)