Science journalists were more cautious. They took issue with the fact that Colossal had used analogous genes from mice, not woolly-mammoth DNA, to achieve the effect of long, thick hair. A professor of evolutionary biology at the University of Buffalo did tell the Associated Press that the work was
technologically pretty cool. But Nature noted that a Maine research facility has been offering its own long-haired mouse strain, named Wooly, for sale to scientists for the past twenty years.Lamm was irritated when I mentioned the response to him.
We are the most advanced multicellular-synthetic-biology company on the planet, he told me. The science behind the woolly mouse had been extraordinary, he reiterated—researchers had successfully made multiple gene edits on a living organism at the same time, a precursor to the quadruple-axel gene editing used in re-creating the dire wolf.It was the most unique germ-line edit in any animal to date, he said.I asked Lamm if perhaps some overpromising by the Colossal brand had tamped down the applause. The word “de-extinction” appears nearly five hundred times on the company’s website; ordinary people could be excused for thinking that the word referred to creating an exact genetic replica of a once alive animal. Lamm responded,
D. T. MaxI was warned when I started this business that some of the scientific community will be, if we are successful, jealous and somewhat frustrated. He added,You would think spending half a billion on deëxtinction and conservation would get them excited.
I rolled my eyes pretty hard when first reading the headlines about this company bringing back an extinct canine species. It was fairly obvious this was nowhere close to the Jurassic Park-like vision of recovering ancient DNA and recreating a live animal based on this genetic blueprint. Instead, the company spliced in a limited set of genes using CRISPR to mimic the visual appearance of a dire wolf and spun this into a massively overblown narrative. They essentially created a new wolf breed and sold it to the public as reviving an entire species…